	   SnapGene      MGTTAGGCGTTTTGCGCTGCTTCGCGATGTACGGGCCAGATATACGCGTTGACATTGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCATTAGTTCATAGCCCATATATGGAGTTCCGCGTTACATAACTTACGGTAAATGGCCCGCCTGGCTGACCGCCCAACGACCCCCGCCCATTGACGTCAATAATGACGTATGTTCCCATAGTAACGCCAATAGGGACTTTCCATTGACGTCAATGGGTGGAGTATTTACGGTAAACTGCCCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCCCTATTGACGTCAATGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGACCTTATGGGACTTTCCTACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCATGGTGATGCGGTTTTGGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACGGGGATTTCCAAGTCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAAAATCAACGGGACTTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATGGGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCTGGCTAGCGTTTAAACTTAAGCTTGGTACCGAGCTCGGATCCACTAGTCCAGTGTGGTGGAATTCgccaccatgggctcacagaccctgccccatggtcacatgcagaccctcatcttcttagacctggaagccactggcctgccttcgtctcggcccgaagtcacagagctgtgcctgctggctgtccacagacgtgctctggagaacacttccatttctcagggacatccacctccagtgcccagaccgccccgtgtggtggacaagctctctctgtgcattgctccagggaaagcctgtagccctggggccagtgagatcacaggtctgagcaaagctgagctggaagtacaggggcgtcaacgcttcgatgacaacctggccatcctgctccgagccttcctgcagcgccagccacagccttgctgccttgtggcacacaacggtgaccgctatgactttcctctgctccagacagagcttgctaggctgagcactcccagtcccctagatggtaccttctgtgtggacagcatcgctgccctaaaggccttggaacaagctagcagcccctcagggaatggttcgaggaaaagctacagcctgggcagcatctacacccgcctgtactggcaagcaccgacagactcacatactgctgaaggtgatgttctaaccctgctcagcatctgtcagtggaagccacaggccctactgcagtgggtggacgaacatgcccggccctttagcaccgtcaagcccatgtacggcactccggctaccactggaacaaccaacctaaggccacatgctgccacagctactacacccctggccacagccaatggaagtcccagcaatggcaggagcaggcgacctaagagtcctcctccagagaaggtcccagaagccccatcacaggaggggctgctggccccactgagcctgctgaccctcctgaccttggcaatagccactctgtatggactcttcctggcctcacctgggcagCTCGAGTACCCATACGACGTACCTGATTATGCAACTTATCCTTATGATGTACCTGATTATGCTAGCTATCCTTATGATGTCCCAGACTACGCATAGTGAGGGCCCGATATCTCGACAATCAACCTCTGGATTACAAAATTTGTGAAAGATTGACTGGTATTCTTAACTATGTTGCTCCTTTTACGCTATGTGGATACGCTGCTTTAATGCCTTTGTATCATGCTATTGCTTCCCGTATGGCTTTCATTTTCTCCTCCTTGTATAAATCCTGGTTGCTGTCTCTTTATGAGGAGTTGTGGCCCGTTGTCAGGCAACGTGGCGTGGTGTGCACTGTGTTTGCTGACGCAACCCCCACTGGTTGGGGCATTGCCACCACCTGTCAGCTCCTTTCCGGGACTTTCGCTTTCCCCCTCCCTATTGCCACGGCGGAACTCATCGCCGCCTGCCTTGCCCGCTGCTGGACAGGGGCTCGGCTGTTGGGCACTGACAATTCCGTGGTGTTGTCGGGGAAGCTGACGTCCTTTCCATGGCTGCTCGCCTGTGTTGCCACCTGGATTCTGCGCGGGACGTCCTTCTGCTACGTCCCTTCGGCCCTCAATCCAGCGGACCTTCCTTCCCGCGGCCTGCTGCCGGCTCTGCGGCCTCTTCCGCGTCTTCGCCTTCGCCCTCAGACGAGTCGGATCTCCCTTTGGGCCGCCTCCCCGCCTGGAAACGGGGGAGGCTAACTGAAACACGGAAGGAGACAATACCGGAAGGAACCCGCGCTATGACGGCAATAAAAAGACAGAATAAAACGCACGGGTGTTGGGTCGTTTGTTCATAAACGCGGGGTTCGGTCCCAGGGCTGGCACTCTGTCGATACCCCACCGAGACCCCATTGGGGCCAATACGCCCGCGTTTCTTCCTTTTCCCCACCCCACCCCCCAAGTTCGGGTGAAGGCCCAGGGCTCGCAGCCAACGTCGGGGCGGCAGGCCCTGCCATAGCAGATCTGCGCAGCTGGGGCTCTAGGGGGTATCCCCACGCGCCCTGTAGCGGCGCATTAAGCGCGGCGGGTGTGGTGGTTACGCGCAGCGTGACCGCTACACTTGCCAGCGCCCTAGCGCCCGCTCCTTTCGCTTTCTTCCCTTCCTTTCTCGCCACGTTCGCCGGCTTTCCCCGTCAAGCTCTAAATCGGGGCATCCCTTTAGGGTTCCGATTTAGTGCTTTACGGCACCTCGACCCCAAAAAACTTGATTAGGGTGATGGTTCACGTAGTGGGCCATCGCCCTGATAGACGGTTTTTCGCCCTTTGACGTTGGAGTCCACGTTCTTTAATAGTGGACTCTTGTTCCAAACTGGAACAACACTCAACCCTATCTCGGTCTATTCTTTTGATTTATAAGGGATTTTGGGGATTTCGGCCTATTGGTTAAAAAATGAGCTGATTTAACAAAAATTTAACGCGAATTAATTCTGTGGAATGTGTGTCAGTTAGGGTGTGGAAAGTCCCCAGGCTCCCCAGCAGGCAGAAGTATGCAAAGCATGCATCTCAATTAGTCAGCAACCAGGTGTGGAAAGTCCCCAGGCTCCCCAGCAGGCAGAAGTATGCAAAGCATGCATCTCAATTAGTCAGCAACCATAGTCCCGCCCCTAACTCCGCCCATCCCGCCCCTAACTCCGCCCAGTTCCGCCCATTCTCCGCCCCATGGCTGACTAATTTTTTTTATTTATGCAGAGGCCGAGGCCGCCTCTGCCTCTGAGCTATTCCAGAAGTAGTGAGGAGGCTTTTTTGGAGGCCTAGGCTTTTGCAAAAAGCTCCCGGGAGCTTGTATATCCATTTTCGGATCTGATCAAGAGACAGGATGAGGATCGTTTCGCATGATTGAACAAGATGGATTGCACGCAGGTTCTCCGGCCGCTTGGGTGGAGAGGCTATTCGGCTATGACTGGGCACAACAGACAATCGGCTGCTCTGATGCCGCCGTGTTCCGGCTGTCAGCGCAGGGGCGCCCGGTTCTTTTTGTCAAGACCGACCTGTCCGGTGCCCTGAATGAACTGCAGGACGAGGCAGCGCGGCTATCGTGGCTGGCCACGACGGGCGTTCCTTGCGCAGCTGTGCTCGACGTTGTCACTGAAGCGGGAAGGGACTGGCTGCTATTGGGCGAAGTGCCGGGGCAGGATCTCCTGTCATCTCACCTTGCTCCTGCCGAGAAAGTATCCATCATGGCTGATGCAATGCGGCGGCTGCATACGCTTGATCCGGCTACCTGCCCATTCGACCACCAAGCGAAACATCGCATCGAGCGAGCACGTACTCGGATGGAAGCCGGTCTTGTCGATCAGGATGATCTGGACGAAGAGCATCAGGGGCTCGCGCCAGCCGAACTGTTCGCCAGGCTCAAGGCGCGCATGCCCGACGGCGAGGATCTCGTCGTGACCCATGGCGATGCCTGCTTGCCGAATATCATGGTGGAAAATGGCCGCTTTTCTGGATTCATCGACTGTGGCCGGCTGGGTGTGGCGGACCGCTATCAGGACATAGCGTTGGCTACCCGTGATATTGCTGAAGAGCTTGGCGGCGAATGGGCTGACCGCTTCCTCGTGCTTTACGGTATCGCCGCTCCCGATTCGCAGCGCATCGCCTTCTATCGCCTTCTTGACGAGTTCTTCTGAGCGGGACTCTGGGGTTCGCGAAATGACCGACCAAGCGACGCCCAACCTGCCATCACGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGGTTGGGCTTCGGAATCGTTTTCCGGGACGCCGGCTGGATGATCCTCCAGCGCGGGGATCTCATGCTGGAGTTCTTCGCCCACCCCAACTTGTTTATTGCAGCTTATAATGGTTACAAATAAAGCAATAGCATCACAAATTTCACAAATAAAGCATTTTTTTCACTGCATTCTAGTTGTGGTTTGTCCAAACTCATCAATGTATCTTATCATGTCTGTATACCGTCGACCTCTAGCTAGAGCTTGGCGTAATCATGGTCATAGCTGTTTCCTGTGTGAAATTGTTATCCGCTCACAATTCCACACAACATACGAGCCGGAAGCATAAAGTGTAAAGCCTGGGGTGCCTAATGAGTGAGCTAACTCACATTAATTGCGTTGCGCTCACTGCCCGCTTTCCAGTCGGGAAACCTGTCGTGCCAGCTGCATTAATGAATCGGCCAACGCGCGGGGAGAGGCGGTTTGCGTATTGGGCGCTCTTCCGCTTCCTCGCTCACTGACTCGCTGCGCTCGGTCGTTCGGCTGCGGCGAGCGGTATCAGCTCACTCAAAGGCGGTAATACGGTTATCCACAGAATCAGGGGATAACGCAGGAAAGAACATGTGAGCAAAAGGCCAGCAAAAGGCCAGGAACCGTAAAAAGGCCGCGTTGCTGGCGTTTTTCCATAGGCTCCGCCCCCCTGACGAGCATCACAAAAATCGACGCTCAAGTCAGAGGTGGCGAAACCCGACAGGACTATAAAGATACCAGGCGTTTCCCCCTGGAAGCTCCCTCGTGCGCTCTCCTGTTCCGACCCTGCCGCTTACCGGATACCTGTCCGCCTTTCTCCCTTCGGGAAGCGTGGCGCTTTCTCAATGCTCACGCTGTAGGTATCTCAGTTCGGTGTAGGTCGTTCGCTCCAAGCTGGGCTGTGTGCACGAACCCCCCGTTCAGCCCGACCGCTGCGCCTTATCCGGTAACTATCGTCTTGAGTCCAACCCGGTAAGACACGACTTATCGCCACTGGCAGCAGCCACTGGTAACAGGATTAGCAGAGCGAGGTATGTAGGCGGTGCTACAGAGTTCTTGAAGTGGTGGCCTAACTACGGCTACACTAGAAGGACAGTATTTGGTATCTGCGCTCTGCTGAAGCCAGTTACCTTCGGAAAAAGAGTTGGTAGCTCTTGATCCGGCAAACAAACCACCGCTGGTAGCGGTGGTTTTTTTGTTTGCAAGCAGCAGATTACGCGCAGAAAAAAAGGATCTCAAGAAGATCCTTTGATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCACGTTAAGGGATTTTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTTAAATTAAAAATGAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCTGACAGTTACCAATGCTTAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTCGTTCATCCATAGTTGCCTGACTCCCCGTCGTGTAGATAACTACGATACGGGAGGGCTTACCATCTGGCCCCAGTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCTCCAGATTTATCAGCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGTCCTGCAACTTTATCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAGTAAGTAGTTCGCCAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGCATCGTGGTGTCACGCTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGATCAAGGCGAGTTACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGGTCCTCCGATCGTTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATGGCAGCACTGCATAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGACTGGTGAGTACTCAACCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGCTCTTGCCCGGCGTCAATACGGGATAATACCGCGCCACATAGCAGAACTTTAAAAGTGCTCATCATTGGAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGCTGTTGAGATCCAGTTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATCTTTTACTTTCACCAGCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGCAAAAAAGGGAATAAGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTTCAATATTATTGAAGCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTGAATGTATTTAGAAAAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAGTGCCACCTGACGTCGACGGATCGGGAGATCTCCCGATCCCCTATGGTCGACTCTCAGTACAATCTGCTCTGATGCCGCATAGTTAAGCCAGTATCTGCTCCCTGCTTGTGTGTTGGAGGTCGCTGAGTAGTGCGCGAGCAAAATTTAAGCTACAACAAGGCAAGGCTTGACCGACAATTGCATGAAGAATCTGCTTAGG  <›            #      &                     $       /   (               $                                    &                                 "                        "   )            6      #   4      *   &   4            &                              &   %               $      3                                 !                                          !                                                         '   "   -            &                      /   *      	                                                      !                     *   (   #      "   ,                           %               "   #   %            %                                 )   4   %         ,                         #               .   %   "   4                     *   $      (      +            3   +      "   '   2      *      !   /   $   2         Y á®Ý×?h8	9	ª	Þ	1
V
_
`
Ý.Ö™ÖZxågWi á xâ bYœ¼÷i¢:	ÕÞwµºÎ=[¸æhe@¯ç› Z ÷ MŽ	•	«	
a
Š
D1Ü,×yÁ/j#  ÈNÃ¯ÞÙiÒØ@M!	¸	ß	
2
W
W÷/‹Ê×šs)û­pXï t û cDÝ�;	Q	€NZxàhçœ÷& ´ù�Ô¦½É5ŽÊj2	M	]	a	¨ 7¶l0b¹s˜f›,l°IÐèø Îãžî.—	Öß�Ÿ¥ÀÜh�ÒI\iK$ûA\hB– â y!Z€‹QTø:£Ë–g»Š5AÏ> o ø ¬_±}8N±_�	
‹
�
E2zÝSÿ-zï•>TÎõÑÂ Œ MR’}
b
�9NˆÞø3z§È ´ÕÂ}Ó¬	“
KkîÌ7Ø%“ØïVÑR‘0k [ fÙÀÿ–	±	¿s$$›H¤�_±ú$  ÉOVßã¬3
y
‡
0ŒË½Íå2ilìü2K±òn;-ùYð  ]‡º.Úó|ÙAj¤ÙNr	½	6
(O—ømØ¶Ãí—Ô#/ œ {Ä/c„]AFæ>	¹	 
X
ë
C‹Qcåí!u~À0›¶(Mt*E,¿®bJ((   “ T°ø ?_ž½ _Ó˜¼Ûî"	à	
:
Xæ#)]Ô‚	$Úˆ“¥W!q| dÇÐŽ<	!'LO[£ãkÐêí1Áø E·úR	Ó	™áûèN:êx� u ü ír‘	�Ài„íG¢š¸0Ô  t˜!ÅÏYgÞ)ù9yX\‘cÊ]ˆ5€Ð-uÅ>$ úÕ6ËükN	^	
S›D°·ÎmŽ`cgOl‹}m|±rÑ"< žÊþ3	F	8€ýKß!9ºtõœó1J\ùY µ¾�	![öo1ÕaìéN? G§U�b	©·_©x™º-2  ¯ízœºH ½i‚èJÀ„Ë % ÏØ/È	dWj
L2C 7 ä‡¥ï˜?Ì×àþ³Áœ%èBPQ Ÿ¹	I
Ž“¦Ý+|…ÓM]±ü]iÒ'9gizž—Ÿ§ ¹ Å î AJûE:R~Äq¤	o	hzhˆ¤‹Ê½ð?Íà"�“ 1 [�ðUŒýà;TT	}	›Büýp©ó1 > ã zÚ"DUÃù—
ó¼ÐòÍµ   « pÌäôp;æ2;ÌÕ	¢
0FJ@Þ6xäè;Ì<ü-& ù Ì`¯²{~,‰3KO,–ª¯]Ž
‘
U”5}Þ| "0ÖðlRUÏ*ó ­µ9Îü
 
FJÜU7†~¿ËÒÃ #Y­y‡²»`‹�	Œ
%'3{.5m–²ýöƒñðò &=i�´TžÑ„{Ä*´?(F=’„ S¦t
RG…˜8¨Éÿ¾ M � Õ N2oOžßùœºu¼‡ È þ %•PEYrc
VžŽíýö:‰4t{’	óRß  3j‹¾[“Ø~îxt�ŸbÖ½ . ~“�ÔJb�’	}§J&Ó�«¤ë©ÛÞCkyuþô   C ~ ”
ï-”?W’;­É2S…’1Ö  µÖ‚½š	ï	lª6€Ù.ð´ÒÚ€Ð»" c w Ì Ãž	­	
ä
L‰žïÍ8�®ÂÙk(6‘ŸÃIàÁP€l /e	—	Å	.
yÙµÁ%œú�²û \ ¼ ñ D›þÚâ/m éõ
)o·%Aªå%éIøn°â ígÁ„úÀtùè¥×ž7 ¨3rÎï ½t§´²	ƒ<„ÄOÝSï‚` ²ÓP ÉÙì¨	4
w
…
ˆ
s³3jÌXãí07L<ÌP÷@  äÌIZÎæmÝî3ó/Ð8.úZñ
  , | ÊW€à­øí	ž
�H›ô©²j¹"  žh	N
m
z
ƒ
™
³
»
)1q– ¾À¤V áý,oÓ�îwÔ%q) ˆ»qá±ÛHÚàk%
7
F
P
›
LP”˜É+dn˜Ù¡‡p*âåðy€˜/ HÇôÔB�¥Çs	Zs¢»j ‚�·Þ-Z‡ÖHÇÕß$ ^‘�Þ)ÉÚ|
_c§«¯!S“Â¦¦½ËfÍÒî ¦%Ñ8 /iøh}¶OŠ	¾	)Åù^¶Ä›”s6  � #,0ÌÑ$d•¦/4�Á47Gn€àº	S
û	"›Á)]uFe+Ê-®‚ª¯ÐˆÅ*rþ ¡|?_­Ï…¯«¯'L¯?	j	¦
;æîvÄ1:NŠAc´ç#  Žè[7R^ Ê
ì
!Rd{Ø'ïe|†+Š­Dq¶Ãì)E4 všÅ?†–O$níBƒç!
Y
Á
ú
DŒq òœ·–F¢ÿ @Àã".|£ƒ«%CKýW?Æå $ã#	è
$*ÕÓøp¦ó
%“B_¦Air¬}ÜÎ* ! Ú .»ý±ù9Ÿ©¾ÄHß�á	(
@
¯
ß
Yƒ¢²üÆÛ‰”
ŽeÅáµ'†Û& ˜ Y(¢'¡Õê+`?'+‡Üï 	&	.	ç-3^ë«µt}WÕXî“4 j ” ¤ ² 7Ue=Òkt©˜´@[`r	!Ô™0½	é	
;
o
µ
½
_sÉÕÞêôÿ3V8Æór©ÅÈ" à X›Ü»Ñ>·	
^
CÔ0-¹˜f?oæî.h ÈÜ�P	`	Mž¤fÛ€Ñ@r—ÿ#nú[gÏ e¿þyË$î‡š2ù&  UbŸ>�â£=	
9
BNŠ–"(P\bälµ¼ëJ‡’¤¾:Âì,Ó"' s Xìù ˜â�béì,F¡· Fû€	RšCü`wkò{që1X> $ ¸yH
¼	çOhP¿yž Ëãó9oT Â	S	|	Ô	gš Eü; "¬h´2JÍT“IÐl…Q)¾'~‚ð<ƒ L Ô ý 2iŠ½×sU�F s‘›¹½tÕ¼Þ B b v ’
,îÁjÒ�H‘£¬êÀÈÏ1xÕ šì§qÍî	‚;nƒ¶Ã´èî�á ÒÈv
‚
�
²
º
(p²HYG£ËíU6i.ËÏvO¸?& pÆh�°Ý÷(gÓßE
K^r“¦º]’Ÿ¥¼e�ŒÑ)áäYš.¥Æ$% u�™"…ËÐZ¬Î®m®ìmR
ù
ú:pzšd‰*‰É?!©ª³V i ü¡¨³Ô8qÃ*G'
o¥^sÇ�dhÚ žœýO	_	
Ó¸»#I†‘£mù>Zn+fÒåí!& ë {	—»D�avû ¾= !1ëÖÌ
:T‚œEÏÿkçP~�}¼swà;‚$ oŒû„ Ê«Íö7pl�
ø
]¥o±Gnìž»dr h¨Œà²N#Ù ŸÉ�Ìÿz	9\�¤nþ"�ºjqHu…�¢ŸøY�M:ä�3 *Ëõx	y	…	678òóôlm„� ¡ÙÚ�žôõö÷2WXwxJKL9K]ÉÊ×áâãZ[€ � P+Jövÿ
õà™­¶:Ûry…Øú\d 	†4	G	†	¤	9£Lá»ö¹½3ž_L^Ë` � Â ô GQÅ,K¿ÇÖ<ö"\pá�ê�Òyz³/ÙûO I ¿ Ý DW	u	‚	ä	�÷š¢·Q\Ìíê]e S ¶÷W	j²®;L—s¥¤4 O ãwÃ 2ÖbÜ†ŠºÁ@ ¨ × å5§5	‡	¥	+
Þm.Ø$M 4H¨V�H	ª­¸ýMVy ºÌa … 
7‡�B	:¤Ïä`ª{â�á\4Ÿ‰3_š ó“—çÉc	´u½÷¼š÷»ó¾`Ü‰! r ‘ õ RvªÆLÁ×{ÀÈ×R[}I¾
jãýq‘"�•¯ Ã HnîBš¸Œm	÷¡±ñ]ƒâK‚ÓL{˜07<:  Ê -v�»*#ë÷|6A…üP ,c°ßY¤‹©=JXa ©Äécz´³ÁõÚÌ J g Ò Þ ÐEËC
e‘ÁE£(¼èÍî,fÓ ƒ À mtv	ƒ	¢	ÑŽ›¸hk]¢ë^ & n p *kÙ�øX”–H ( z0X	É	å	#ÿYRM3 	D 4 ; ¶ ë >øB“OÜÛ	ë´ÂÇZ„<˜ø¦äF45 8 F T _ `—¤ˆ¦ð~
@k³”Ï&éQt¢  åQødÍØáÿ
‡¯¿vCÛR'JTw ·X™Äø>é<�ÍM¥å ž’!\§yPU�¨²3×Ýåðh˜ P 'ÂºäG”}•ú=ÿ¨çô<cÔT‡»V(ˆC+! �ëà+Û	J
ºe­�Þè†Ô^ï‹}ý^‹ÊÓjŸ¨ ÂáA  ^ü”²xÄe
	Ùƒ,NBZÚ²jä�™:¸{¨  W Š Kß]6z6	K	p	Œ	&i‰Ë‹T`ö” © S|	i†Œ¾[Î¸ /	% º Æ ï B“ü;¨r¥²,
â
P{‡¥`9ÙNŽ * Ø 5FæÇ%2Åˆ	¦	ç	k
—
Ç%ñ@ßná€ì#Aû É7½ÚV�Òþ<¬Á<~	œþ^ý!DqªêÍ 5‚ñ3©‘áóUU	«¹û—«´JT×»b¿2 2 � l�ÀÝ\W¢NCW’z5*Fu I1äµI	©
®Rþfô  ð
E‹&¸ÐQC	¥ôa­½«È¦�­Î› ? ¤²Äâ]h † ä {ƒ#ˆKE�ú«
;| Š4¯ Û8kKVÀ	˜°ÐådÑãŽD5ó‹Ø`Ž¶ ¡ •q<újZ	Ð	£
G7yå›HÍÂ5Gý"o. §¾ˆ”âv¾ADé¿°aÝµ qõbô€˜ç<eƒ¡èå“Í+Kí4ø½O•dÆ‰ ¬ óÍåæ·3vÊd	Ë	Ö	 

1µßQvø<¼ô=Š– ö wÇMaÂ­ØLhÖL 	”	Ý	U
VÜÛöÉ+rÕ(wú¬À' s ú Í³øCÓŠ¥4P�ÉSí-9–1	•§6~Y¿ßk‰Hg+Hö" «‘°Ø||Á	|°Ò^�
’
Jíþ’×#Sy¦ÇÐG£€ô�Ð°- ’ › S\†¹z.÷-ò¼Ø@^\—«~¼	}�¿ä#1Lh°ñmV {– ¶ÄÎf(Ï�ø8K¢Éƒ‡ìM™ÀÓéwÄ=  ýE	
¶Z^¯_ 8ÔNŠ| !M; 6 ®†›¤¹>GcËý’²*„VL°18�Ê& 0 = Ÿ ¸ Ä í @IoÙúDï:C1:ÃSpn	¡
y	òÝw¼ãÌ!¨ñÌŒ,  ®%zŽ+†ˆû+•³ºŠ�
$&4|�!/Õ46}±³EÊïñ  $Z¥íwOžDqs
~ìün„—7þò†Q Ë ¼IaŒ‘	�	�­->5Ù¨ÝB„týó .2.¼ƒŸèdÄ	($@N©äxÜøÀRÖ÷m¯6  ±�ëM
•šŸó/+Ò€Óö à�GŒµYb¡ªiÄc †ÊÌµÝ,†GŸ“7/  +>• #N^#¥.ª6KQ€À6‚®ß ŸÃñî\…d­{@‡µ)æÂ>ÅäëD* -dÑ'j&—Z¨>Þ*/�â?
®
2UÒ÷7Åêòû|¨Å@í«à´
Û…Í  ß Ta]
B/a½†™9gH	 òxfjg ¶W A K a Ó ™¦ÌS’mµÂHÑé¿ÎïÔ h Ñ~§¯fF­D
u
¹
F¤)(©ÊU- n‹›ê€
Òú=»v½ìØ Ž O…œuw	„	£	þ
ñœ¹ipŸqv„Ž�^8_ H N Á ;��€–ÑP¹¤Ë£ „ Ö 3A	ÎãŒlà[ˆ q É +buAQŠ™¨·)Z‹l	WŸð5—
”ô® ' o jlsÐ€�þ“• : E ÿ =–£NÃê=èÆYƒ÷uÚ¡3IS &“±ÚFd
¹‚xù<�±îóA;YŠÙä|SÉUŽ‡*à  ) V ‰ 4’\y{Æ$1±æ	–
%$ŠZS_ë € kŒ¿ÙÑã´ò¨
–Ceé4E¾ ‚ï	D±c¬×®
 ¦”‡u‚ Y	Ê	3P GN”¯4!n …¸�¤?ÕK	“	Ü	~ÛìXÚÈKg'ùx¥F¢zGõ / 5 < · ì ?ØùC=xÊµ)»ëM¯vÿ L+ 
*úCp”žcœ	œ}?¨w~ÔÛ=Ø§ÜDl5î! 
 ”"]P¿Ý.Ž­
hÃ”ðñ[…™žò¬ÜìªÒßå	6  ` ˜ñeA.l´'TVG G „Š:
Žð•Ð<puƒ¸£Ê7× 9 D at‰’˜§¶ŠÏ‚Œò@XØRT�†“)2 U  ˆ ¥ñ#•
$‰•F“ê®3«m­ 	 ·×	ùB¾	›	wÉÚWg>Úñw×ÛEÑK ƒd"9‰#�Î ˆ�o‚SŒ6¬(U*  ¶!eø	mnÈÙTUVfˆ<=7ÀÁÂÃµ¶ÓÔÕÖDn�Å«( æ }æ%RG`fòüxð	ù	Æ
Ì
Ù
î
oâ‰«8°Ä/¯·ZsÜÆ±¼x#  ¸êÄý¹ý	®	
Ç
å
pãŠ¬ê=¯žÚ	-o)b’ ˜ÝÂ\T� d aŸ	M±ÅÄaá¢²" îSƒgš«ñ	Í
Ú
ŠÅùÎ9®¸ÃÆlÎ[tJ¦ÇæQ½, x Í ç ~ç&MHZTóYyÐÔôô	ú	Ð
Õ
ï
Ÿð?�~90N°	¸7my œDfº	¯	
/
½ä‹ëf.¶Ø"*c“™]U™ ëÅpÞÆ	.¢>Vz
Þ‚‘³ 0˜	¨z×Ú‚4Â&(�æÞûñÿi�  Ÿ¹“þ"…þ	#
È
Ý
æ
]q­Qž°‘Ÿ©³Ûp¡Ãü V¹&0¡ê
	*p¸&~–>=dêŽÅ'¼ÍWo£,º Q ½ ò EÃÿãnåÁö
²h°•B¹èFåw Uˆ)Úd ] e (œéHb 	æûaåõ &Jâ�±ãAD: ÝÇÛ»cN«ë ©²ÆH�¤BÕ~7bEù‰³% xAŒÂL„,Më›¬éÂ	K
06�‡ÇÓú~…¦ÔÈç¾ÃÈâB �há[
ü
Á¯ÏŒØŸ ìïX‡òûò	Î
‹šÆ:u¹ÄmðéK­_©Rk © îTˆŠÜh…	Û
»f®úÏßéÕ_0\uŒþË§b8¡¸ y :�ôZõÒçñüÑP-:CÂ8TÛ³�d¹n" è èð'¡©4N_e˜QözÅ„ @„RÞO±[¹¥ðåM–š|# ýIðó7[•³jmyïu¨Ñõ	Ã
Ö
‘áôO1
2	kƒYa% Î msÏ¾U
µÕ	)	³	û	f
Ñ
ð

=F…ŽÅÚs˜$^õ ;z£©ç  X àög¡7	�	©	
0
‰
vŠ´ÕÍ<Y·äd®Vš �Ê	L	\	Œg4/aJšk÷A• ‹ L³ÔQ^7°	j¾6RrŒî#8MU”Ý÷=ÍQ^% ^{ƒE»Úåíq	5
x
†
ê
'åÓì t/Ì'kDÙ+1aµIø —Æq	Ò	&júW[Ï¿\4Ï09t/ÿ TÍJ�¨õnÞô¹0[~  ì×Ç	{ç›Ñ
&fƒ¦ ª üå}ß/I‡£?Éçïßû:Ëûò’´0 ËX<x©®\Ÿ
{ÛTƒÃ)küò‘ Ç ”1€XQaõ�»  - } �œ™	î	ã
|ˆ©Ž¦I5œ'ª³žÂ:ßÚjOº » ð Cýáls¦³ù-
ô
Øçù �  + { ŸØ÷g	§	ì	l
„
˜
rŸ¿ÜWàâ¨í7$p	 GÈÆ‰	$
O
{
š
®È*—RÁ ¥oïxÕÞrÐ)   ç>”&3ÿ3i	¥
À
É
×&9{•E¡¬þâ-Cp�¢Ï‚Ä$Büqý4 — £ ± Ù 6X<ºsé#&†ÿ	%	-	è	n
´
¼
Þ
ç
^rÈÔÝéóþ,2¡±’ª´òAqÄVÔ	’Ä&% Wš¾Ûº=Ûá¢=¶	
8
AMx‰•�Ê,eÚ—´?eq–þ"ëÎ- # rÊâ8nSWÿøÁ		G
Q™Bÿ_ë+EæñOzp0 h‰¼«g³p1I+í³�r�(«½&œÇ�~»Ý, Ž²ÓÜ'­ÂÒlëÇ&
Q
œ
±
Jq’¹'o™¤¢TˆÈ>‹ÆãÎXcg™¤·  0êƒªõo
÷
–ºCFºëæ§ß*ße % )IÈô5¢[£k˜¬µàGƒŽØ¸¼VIÈÖàc  R ¾ Ü ó FÄ ÆÕCâVÂV	t	ã	i±¡éKx‰².[À3 § 6äò4’–Žæ¦È*
¬³t¼üözUÝòˆ×#Û™ m©ÀÖÞXu£I|`¨°	Ãâübö!{K6@Ž²;9 f m ‚ Ñ )yÊ¡	B
À"D'Xg»ç¡+GÒ 3 ^ µ ê _÷AP’cÛÚ	}
÷†;¾Ì“ÎãäE&v# Ž�Áê]û‘ß* [d¬ØçOT”§þ§æÓã˜ï·B§ ÞJ	‹	j
á
O†Æ…_·ÿ8@úõ ÈÜ6¼02;¡«Àúª³IQS‘]Ö)t £ÿJj~Š%J·ÏP¿	ª
¯¬Ç¥CgŠœ� ò½aåùi¶dáä’Ï	ÿ	
*ìCuÁcÅF•´ˆ. š [y÷-B¬Òö×ñŒ»]gì{Ñ8•0	»	T
¦õ€¾ˆ*ÔGfv¯«ÆÏ¿% ž ÃÍe'09…£ÂRoD	bü7‘Y®^vÈË‰ §ðèœ‹Éÿ" $1�¤…ì-N‚¹çH‰Ã	r
#Mœã¬ û,3¿4Qƒ°Õ®És4  Ð*ÿ%M–"F§-5)5�œ­Þáê>
L
1
bÂö6íúÉ§Ë.?Ñ†+…žÄãêC @ }¥`w®¬\
¸
`Ðifµ ›šé@	ý
Íâ‹Z� <¢i@°(Mk	¸Âé<çïwÅ;°ãÈÙ ­ �‘ÐâC†°³Å°§
2OB^dè „�!)\£>o-¬
<›|Ù“ï(vðfº}êL®¡í* ‡ s‰ð‘—µ‹ñE×·ªlF* å |$Fc 8A_ˆñûw	÷	Å
Ë
Ø
í
"vŒÇSe;‡®Yrm‹Ä5ª°$  í
Lé
‚YSª¸ÏÓóü	ó	Ï
Ô
}­·Å,na—`[S¡ ›oÝC„"
Ü
-¼¡e�Ö�!'þ�( ÜÆèU¸%bÀ		±g¯ê¸`äG�£AEäv}�ÿ&6ÌDŒÙ@c9¹ w@‡‰‹KLWê†èñÁ	Z
û
™/5Ò
 /„¬¨a·Ç+ ï9d—Pl€òõ6ilî		(	Â
E�ÑæûrÐàó—QÁ#1]¤ôL•Xc¢æ ]‚õä[	é
uÒ5QÔ.q&;C`IÜö´Hj­ –ûÖÑ	%Hù§Èôšæú9Êseþ}¥/ wkW›[ó
SœÁøº3 z – ¢ ° W;r=è%2×ö$	,	f	ë	¤
¿
ÇÓÜèòý+Ö8z”D«§ÃBUÎÃ6‘~#pÝoÏ+ " gªfm™²RoÑ÷ÀÆµ	
°
@Iwˆ‘ìA£³S²ÇŠ•�%Nbf›Æ}¶Ü ¦ Û /é(•Åâ	

)
4¡EêõyßÜ¦ñ±"Þ˜" l ´ Ð é ¨ö@¿ÕOútx{Ù	A
Z¿×ö…:áýºæ—â?¶' ñ¢¼þ5`:‰ ª¿$IÎàã‘Î	þ	
i
à
…„BtP\À?(Œ‡2 ™ ZÏö)£«õþÖë!º,8\f„¢zæ(ˆ”Ý/	=
q
aLXâõ5ìù2u¾Ê3>Pï„Šé ;€všB™è·
·èÌá_~YeÇ¬* r		 (�¢b=–´@nð,v©·ÎÒ		ö	Ä
Ó
×
u’î¬¶X`Ö–
lZ çcJ·ñô5aék¿ð	'	,.4€P	&”b! • ¯ Vvç\ÕVš1Ö+	e	ê	¾
ò
ÆÛt4ÇR™ªùÀÉõ÷|¤/ k ¥ ³ Ï fõ?ÔlnsÐ#w¿Í´	Í	Ø	ý	
	

h
3?H‡�Öëõ9àôsx$>!>‹—$ :Îæªu™¶ Aa¹4¶¾		<
p
¶
Ò
`t¶ËàWÉ%=_«è2 ­ ® 89ô>Óutµ¸
"ËÌ*	Ì	×	ü	



g
ñ
2>G†�Êß wÆÇÈ½¾¿ö#<={ª  /`  qGACNNNNNNGTC,CCAGGCCTGG,GATCCGGATC,CCWGGTACCWGG,CCANNNNNTGG,CCAGGNNNTGG,CCANNNCCTGG,CCAGGNCCTGG,GCACNNNAACGTTNNNGTGC,CACNNNGTG,CCNNNNNNNGG,AACNAACRYGTGCGTGC,GCACGCACRYGTTNGTT,GCACNAACRYGTTNGTGC,AACGCACRYGTGCGTT,GACNNNNNGTC,GAANNNNNNNTTGG,CCAANNNNNNNTTC,CACNNNNGTG,AACACNNNNGTGC,GCACNNNNGTGTT,GCANNNNNNTGC,GAACNNNNNNTCC,GGANNNNNNGTTC,CAGNNNCTG,CCAGGNNCTG,CAGNNCCTGG,CCWGGGCCC,GGGCCCWGG,CCWGGGCCCWGG,AACNNNNNNGTGCACNNNNNNGTT,GACNNNGTC,GAANNNNTTC,CCWGGTACC,GGTACCWGG,CCWGGWCCWGG,ACNNNNGTAYC,GRTACNNNNGT,CCWGGYRCCWGG,GAAGNNNNNNTAC,GTANNNNNNCTTC,AACGGCNNNGTGC,GCACNNNGCCGTT,GCACGGCNNNGTT,AACNNNGCCGTGC,CGANNNNNNTGC,GCANNNNNNTCG,CGATCNNNNTGC,GCANNNNGATCG,TGANNNNNNTCA,TGATCNNNNTCA,TGANNNNGATCA,TGATCNNGATCA,AACCTGCNNGTGC,GCACNNGCAGGTT,GCACCTGCNNGTT,AACNNGCAGGTGC,GCCNNNNNGGC,AACNNNNNNGTGCMC,GKGCACNNNNNNGTT,CCWGGNCCWGG,AACTGGGNNGTGC,GCACNNCCCAGTT,GCACTGGGNNGTT,AACNNCCCAGTGC,GACNNNNGTC,GAGNNNNNCTC,CCWGGTCTC,GAGACCWGG,GATNNNNATC,GATCNNNATC,GATNNNGATC,GATCNNGATC,CCWGGCGCCWGG,ACNNNNNCTCC,GGAGNNNNNGT,AACNNNNNNGTGCAG,CTGCACNNNNNNGTT,GATCATGATC,CCWGGNNCCWGG,AACTGGNNNGTGC,GCACNNNCCAGTT,GCACTGGNNNGTT,AACNNNCCAGTGC,AACNAACCGGTGCGTGC,GCACGCACCGGTTNGTT,GCACNAACCGGTTNGTGC,AACGCACCGGTGCGTT,GCANNNNNTGC,GCACNNNNNNGTTCGAACNNNNNNGTGC,CCTNNNNNAGG,GCNNNNNNNGC,CCANNNNNNTGG,CCAGGNNCCTGG,CCTGGCCAGG,CAANNNNNGTGG,CCACNNNNNTTG,TTTAAACNNNNNNGTGC,GCACNNNNNNGTTTAAA,GCACNNNNNNGTTTAAACNNNNNNGTGC,CCAGGNCCY,RGGNCCTGG,CCWGGGNCCTGG,CCAGGNCCCWGG,AAGNNNNNCTT,GAYNNNNNVTC,GABNNNNNRTC,GAYNNNNNRTC,GATCNNNNVTC,GABNNNNGATC,GAYNNNNGATC,GATCNNNNRTC,GATCNNNGATC,GTYAACNNNNNNGTGC,GCACNNNNNNGTTRAC,GCACNNNNNNGTTAACNNNNNNGTGC,GATCNGATC,TAACTATAACGGTCCTAAGGTAGCGA,TCGCTACCTTAGGACCGTTATAGTTA,CTCTCTTAAGGTAGC,GCTACCTTAAGAGAG,TAGGGATAACAGGGTAAT,ATTACCCTGTTATCCCTA,GTTAACNNNNNNGTGC,GCACNNNNNNGTTAAC,AACNAACGCGTGCGTGC,GCACGCACGCGTTNGTT,GCACNAACGCGTTNGTGC,AACGCACGCGTGCGTT,TCCAACNNNNNNGTGC,GCACNNNNNNGTTGGA,CAYNNNNRTG,AACAYNNNNGTGC,GCACNNNNRTGTT,GTTTAAACNNNNNNGTGC,GCACNNNNNNGTTTAAAC,CCWGGCGCC,GGCGCCWGG,CCWGGNNCC,GGNNCCWGG,GATCGCGATC,AACNAACATGTGCGTGC,GCACGCACATGTTNGTT,GCACNAACATGTTNGTGC,AACGCACATGTGCGTT,TGGCAAACAGCTATTATGGGTATTATGGGT,ACCCATAATACCCATAATAGCTGTTTGCCA,ATCTATGTCGGGTGCGGAGAAAGAGGTAATGAAATGG,CCATTTCATTACCTCTTTCTCCGCACCCGACATAGAT,AACNNGCACGTGCNNGTT,GAACNNNNNCTC,GAGNNNNNGTTC,CCAGGWCCY,RGGWCCTGG,CCWGGGWCCTGG,CCAGGWCCCWGG,CCAGGWCCTGG,TTATAACNNNNNNGTGC,GCACNNNNNNGTTATAA,GCACNNNNNNGTTATAACNNNNNNGTGC,GAACNNNNNNTAC,GTANNNNNNGTTC,GGCCNNNNNGGCC,AACNNACTAGTGC,GCACTAGTNNGTT,AACTAGTNNGTGC,GCACNNACTAGTT,AACNAACTAGTGCGTGC,GCACGCACTAGTTNGTT,GCACNAACTAGTTNGTGC,AACGCACTAGTGCGTT,AACNNNAACGTGCNNGTGC,GCACNNGCACGTTNNNGTT,GCACCCANNNGTT,AACNNNTGGGTGC,TTAACNNNNNNGTGC,GCACNNNNNNGTTAA,CACNNNNNNTCC,GGANNNNNNGTG,CACNNNNGATCC,GGATCNNNNGTG,GATCTAGATC,CCANNNNNNNNNTGG,CCAGGCCT,AGGCCTGG,CCTCGAGG,GATCCGGA,TCCGGATC,GGCGCGCC,GCGATCGC,CCWGGWCC,GGWCCWGG,GATCGATC,GATCATGA,TCATGATC,GCGGCCGC,CCTGGCCR,YGGCCAGG,CCWGGNCC,GGNCCWGG,GGCCGGCC,RTGCGCAY,GATCNNGA,TCNNGATC,CGCGCGCG,CCTGGCCA,TGGCCAGG,CGCCGGCG,GTTTAAAC,GATCGCGA,TCGCGATC,TTAATTAA,VCTCGAGB,CCTGCAGG,CRCCGGYG,CGTCGACG,ATTTAAAT,GCCCGGGC,GATCTAGA,TCTAGATC,CACCTGC,GCAGGTG,CCTNAGG,GATCGAT,ATCGATC,CCTCAGC,GCTGAGG,GCTNAGC,CCTNAGC,GCTNAGG,GCTCTTC,GAAGAGC,GGTNACC,CGGWCCG,ACCWGGT,RGGNCCY,CCTGGAG,CTCCAGG,GGTGATC,GATCACC,GATCNGA,TCNGATC,GGGWCCC,GAAGATC,GATCTTC,CCCWGGG,TCCNGGA,TCCWGGA,RGGWCCY,TTATAA,AGGCCT,GACGTC,GTMKAC,TCCGGA,TGCGCA,ACCTGC,GCAGGT,GGTACC,AGTACT,GGYRCC,CCGCTC,GAGCGG,AACGTT,YGGCCR,RAATTY,CTGAAG,CTTCAG,CACGTG,GRCGYC,AGCGCT,CTTAAG,ACRYGT,ACCGGT,ACTAGT,CACGTC,GACGTG,GWGCWC,GTGCAC,CYCGRG,GGGCCC,ATTAAT,CCTAGG,TTCGAA,GCTAGC,GKGCMC,TGGCCA,GGATCC,GRGCYC,ATCGAT,CACGAG,CTCGTG,GGCGCC,GAAGAC,GTCTTC,GCATGC,GTATCC,GGATAC,TGATCA,ACTGGG,CCCAGT,CTRYAG,RGCGCY,AGATCT,GGNNCC,CTGGAG,CTCCAG,CTTGAG,CTCAAG,CGATCG,GGTCTC,GAGACC,YACGTR,CCNNGG,GAATGC,GCATTC,WCCGGW,GCAATG,CATTGC,RCCGGY,GCGCGC,GAGGAG,CTCCTC,CGGCCG,CCCAGC,GCTGGG,GTGCAG,CTGCAC,CGRYCG,CGTACG,CGTCTC,GAGACG,CCATGG,TCGCGA,GDGCHC,TGTACA,TCATGA,ACATGT,GTATAC,CCWWGG,CTCTTC,GAAGAG,GCNNGC,CCRYGG,GTTAAC,RCATGY,TACGTA,RGATCY,GCGATG,CATCGC,GCAGTG,CACTGC,CCCGGG,CCGCGG,TTTAAA,GGCGGA,TCCGCC,GAGCTC,GATATC,CTGRAG,CTYCAG,CAGCAG,CTGCTG,GAATTC,ATGCAT,CATATG,GTYRAC,AAGCTT,GTNNAC,TCNNGA,CAATTG,ACGCGT,TCCRAC,GTYGGA,GCCGGC,CMGCKG,GCCGAG,CTCGGC,CTCGAG,CTGCAG,CAGCTG,GTCGAC,CTYRAG,AATATT,GATCGA,TCGATC,GACCGA,CACCCA,TCGGTC,TGGGTG,WGTACW,TARCCA,TGGYTA,TCTAGA,GGATC,GATCC,CCWGG,GTCTC,GAGAC,GCWGC,GGNCC,CCSGG,GGTGA,TCACC,GGWCC,GCAGC,GCTGC,CCATC,GATGG,ACGGC,GCCGT,GCNGC,CCNGG,GCATC,GATGC,ACTGG,CCAGT,GGATG,CATCC,CTCAG,CTGAG,GGGAC,GTCCC,ACNGT,CTNAG,CAGTG,CACTG,GACGC,GCGTC,CCCGC,GCGGG,GANTC,CGWCG,TCNGA,CCTTC,GAAGG,GTNAC,GAAGA,TCTTC,GAGTC,GACTC,GTSAC,GAWTC,GCSGC,CASTG,ATGAA,TTCAT,ACGGA,TCCGT,CGCG,CCGC,GCGG,GTAC,AGCT,GCGC,CTAG,GATC,GGCC,CCGG,CATG,RGCY,YATR,ACGT,TGCA,AATT,CCTC,GAGG,TTAA,ASST,TCGA                                                                                                                                                                                                                                                                                                                                                           1                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
                                                                           	                                                                                                                         	         1   	                                                                                                 	                                                              	                   
                  	            8   !                           	   	         	                              	                                             3         %   "         (         –   [                     c                                                                                                                                                                      1                                                                                                                                                                                                                                                                                                                  
                           	                                             	   1 	                                 	                      	       
      	    8 !         	 	   	          	               3   % "   (   – [       c   uš  vÚ  vö  w6  {Â  €æ  ‡jæzFàÎOk wts•Ð8a›Î1vÒÝ/	´	×		


)
p
¶ý8SÜŠœBYò62P˜€Ê'8
Ý¤JPû‡Ì” U˜i‰í'Ê  €ç7
Z¢ ” .U²Ê#k[˜Õ¦­'+‡ãïj	7
P
z
|
¦
Á
ß
Z¢Õ$*"v�“·æót ô7©åiªÄn�¹;Ýò<˜¹Ýûò¹Ýò¹Ý˜¹ÝŽ©62âïŽõ«@ˆ•±	-�xjõº
“|…—­£õº‚n�·™Ìd$EÿŽ`84v>þÑ9
—Žœ	‹�d]žª´	
ô:þÏŒŸ\¹ î Aûq¤�ý�²M
•Ó4øÉ’}Õ’}(0SzÃ¿
”DÊ5>ØM÷¼Ó�#Ù{µö­®^‰¡¹ î Aûßq¤0ð?�‰* z? ¤:t˜=g´ž\´=’´´’otÒF ”Ï¢_|­«iÒ´M÷T´’÷¼�žt˜ÃÒ@
W
š�'�0ú_§Âc
.KB’ôfnë$¤ÐFr
bƒBè²
º
0ünH
ž’ž®}ÿ Òa	±	Þ	(C‹0Sz˜¿Ã!JkBfd—PõQLê¸äÿcfÓ	:’O_¨¿Õ™ª«¢Ö¹=f[{×´	µ	

?‡%_tÔáuËZ	PHÛÔ-’Ûããè
p%BG¾ŽLòiÓÐH�S
)ªÓ#Ëfû¨¿Õ{á Ût˜Ã=igÒ´@M
W
÷Tž\š´=’J:zý¨¿Õ¢={_áWñ Ž`” U|(,[­ôà+«'0ƒÜãº	é	!
7
¯
½
è
L_”§ÅZœ¢¾Âëï%B©Æ3‰®Þe
¨¿Õ[{×áÝW¢_§Âz’ž	H
�ÜÒ\û\hhyž æ�‘ [O§H€Ç¥œt×ƒo‚62:ÒçñüÂT�t˜ØB®^f‰d—PõQL¡J’ã*-5Þ†µa©). â�²Œ. Y3~â‰O´Lƒ”ý´œ’�² AQö7Üë@•B~‡Ú>˜¹Û ¶céK­ JM:™£3* 8ð	}ôãè
%B2Ç×Q
™ÈÎÃp$ørCoFbQ
™È�²‰o¸äêÿczFäü-•¯	½"]ö LÛ+ÀiŠ½×íÕ¼Fz’
íL’�ž	�¥ÜÒ\û\h–Ÿ+M±i9z§™ Zö™«õÖº\fz”/	µ	
@wˆ³u•í„7R	Ó	™: $•±Û¦k44€à%
P
›
	n˜Á¡‡Ê-Ðâ*˜ “ T¯?_ÿ ÒÓ˜¼Ë!	±	ß	
:
W5!p�_\õtu4Ô;õ­¬8
EÑÂcëbE³ÿË±	5�_±Ûk%
P
›
n˜¡‡â˜ $•¦44€à	ÁÊ-Ð*úZ×ý—¶zH½izp	&Ë` $•±Û¦k4$4€Ùàì#	%
4
P
w
…
›
*Õ	ns˜Á
j“¡‡Ê-0¦AÐâ*}˜÷ÜÎ™ Zö™«õÖ\º\fzõ”/	µ	
@wˆtu4Ô³;u•õ­�Þ)c«S“¦¦Òî¦¯èÀË ð‹Ð¥ô½Îgªf²oì²�%›Æ}ÜŸh�I]ûØã˜·U¸%		�&Ì¹ÃÍe'7Èèÿá x Y÷¢ºÎ=rÎ ½´²	<„ÄŠ K]6j¸i«‹T›qª­ðUÃÍe¸%šé'		7È�&Ìè¹ÿF«g³1I(½&�ÿŠ%·ÏP¬Ç¥œEÄð?à"àø• ¯ Vç1Ö+	e	ê	¾
ÆÛª ¨	ˆ
³ÌXãÚíU˜	�—œÐ1Õaíòµ?}-
‡£ÉØïßù �’œÂ
		6‹�fÇ.ê8™¦doçÈ		�©·ÎÒ	Ó
¬¶`–ZüN	^	
·lmÑ~ Õ 2Ú9”
 
ªÜ”ß’­ø2Ë‡Ž`<ìXòûò	Î
Äm_R í	�íÚU—ÐòµÚ9 
ªÜøË˜œ1Õa?$Ùì#	4
w
…
*Õs
j“0¦A}÷ÜÎ«ÿg³1IŠ%·ÏP¬Ç¥(½&�œ]Ó{:d aŸ	áK	ö”Z¹ + { ŸØ÷g	§	ì	l
„
˜
rŸ¿ÜWàâ¨í7$p	z – ¢ ° W;r=è%2×ö$	,	f	ë	¤
¿
ÇÓÜèòý+Ö8z”D«§ÃBUÎÃ6‘~#pÝoÏ²ÓP ÉÙì¨	4
w
…
ˆ
s³3jÌXãí07L<ÌP÷@ 3j‹¾[“Ø~îxt�ŸbÖ½u�™"…ËÐZ¬Î®m®ìmR
ù
ú:pzšd‰*‰É?!©ª³V žh	N
m
z
ƒ
™
³
»
)1q– ¾À¤V áý,oÓ�îwÔ%q@ }¥`w®¬\
¸
`ÐifµŸ¹	I
Ž“¦Ý+|…ÓM]±ü]iÒ'9gizž—Ÿ§  “ T°ø ?_ž½ _Ó˜¼Ûî"	à	
:
Xæ#)]Ô‚	$Úˆ“¥W!q|]‚õä[	é
uÒ5QÔ.q&;C`IÜö´Hj­m©ÀÖÞXu£I|`¨°	Ãâübö!{K6@Ž²;9  i “ œ Tu{�™Äü"/…¡¨°ËÐøZc ¬³ÎÔ8?_q„ž®½Ã *G_m®Ó]˜ìAFm¼Ûæî"	>	¹	à	
 
'
:
R
X
ë
ù
XæúC‹#):Q]cpzÔåí!u~‚šÀ0o›¥¶	$(Mdt*E‰*^s‰ÉÚ,?ˆ“¥¿!©®ÇWb�ª!Jdhq³V|Ú(' f m o q ‚ É Ñ )+bmu©jlÀÖÞAXu£QyŠ™¨·Ê)IZs‹|l	¡	B
ÐW`Ÿ¨À€°ð	"ÃâüDb�öþ!'Xg{»5K“•—ç
6@Ž”¡²ô+;G®Ò9º Æ ï B“ü;¨r¥²,
â
P{‡¥`9ÙNŽà�GŒµYb¡ªiÄc †ÊÌµÝ,†GŸ“7S ¶÷W	j²®;L—s¥¤4çcJ·ñô5aék¿ð	'	,.4€P	&”bdÇÐŽ<	!'LO[£ãkÐêí1ÁøG „Š:
Žð•Ð<puƒ¸£Ê7×º Æ ï Bq“üeu�™õ";b…¿ËÐôZ€¬Î˜®çþ<emƒ¡®è¨åìmr“¥²Í,
R
â
ù
+P{‡úy:pzËKš¥í4`dø$‰*‰½É?î!O‡š©2•ª9dÆ³ÙVN‰ŽùëÅpÞÆ	.¢>Vz
Þ‚‘³   -<AlignableSequences trimStringency="Medium"/>  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  *š<?xml version="1.0"?><Features nextValidID="21"><Feature recentID="0" name="HA" directionality="1" translationMW="1102.21" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="1743" maxFusedRunOn="1743" detectionMode="exactProteinMatch"><Segment range="1714-1740" color="#cc99b2" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;HA (human influenza hemagglutinin) epitope tag&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="YPYDVPDYA"/></Q></Feature><Feature recentID="1" name="HA" directionality="1" translationMW="1102.21" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="1743" maxFusedRunOn="1743" detectionMode="exactProteinMatch"><Segment range="1684-1710" color="#cc99b2" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;HA (human influenza hemagglutinin) epitope tag&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="YPYDVPDYA"/></Q></Feature><Feature recentID="2" name="HA" directionality="1" translationMW="1102.21" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="1743" maxFusedRunOn="1743" detectionMode="exactProteinMatch"><Segment range="1654-1680" color="#cc99b2" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;HA (human influenza hemagglutinin) epitope tag&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="YPYDVPDYA"/></Q></Feature><Feature recentID="3" name="lac operator" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4670-4686" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-Î²-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="M13 rev" directionality="2" type="primer_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4646-4662" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="CAP binding site" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4739-4760" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;E. coli&lt;/i&gt; catabolite activator protein&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;CAP binding activates transcription in the presence of cAMP.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="lac promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment name="-10" range="4694-4700" color="#ffffff" type="standard"/><Segment range="4701-4718" color="#ffffff" type="standard"/><Segment name="-35" range="4719-4724" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="HSV TK poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2418-2466" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;herpes simplex virus thymidine kinase polyadenylation signal&amp;nbsp;&lt;a href=&quot;http://www.ncbi.nlm.nih.gov/pubmed/3018551&quot; title=&quot;http://www.ncbi.nlm.nih.gov/pubmed/3018551&quot;&gt;(Cole and Stacy, 1985)&lt;/a&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6668-6772" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4476-4597" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3290-3425" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="430-633" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="SV40 promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3110-3439" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 enhancer and early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="CMV enhancer" type="enhancer" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="50-429" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus immediate early enhancer&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="f1 ori" directionality="1" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2668-3096" color="#ffff00" type="standard"/><Q name="direction"><V text="RIGHT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;f1 bacteriophage origin of replication; arrow indicates direction of (+) strand synthesis&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="15" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5048-5636" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="16" name="WPRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1764-2352" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;woodchuck hepatitis virus&amp;nbsp;posttranscriptional regulatory element&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="17" name="NeoR/KanR" directionality="1" translationMW="29048.78" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="3506-4300" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;aph(3')-II&lt;/i&gt; (or &lt;i&gt;nptII&lt;/i&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to neomycin, kanamycin, and G418 (GeneticinÂ®)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;aminoglycoside phosphotransferase from Tn5&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MIEQDGLHAGSPAAWVERLFGYDWAQQTIGCSDAAVFRLSAQGRPVLFVKTDLSGALNELQDEAARLSWLATTGVPCAAVLDVVTEAGRDWLLLGEVPGQDLLSSHLAPAEKVSIMADAMRRLHTLDPATCPFDHQAKHRIERARTRMEAGLVDQDDLDEEHQGLAPAELFARLKARMPDGEDLVVTHGDACLPNIMVENGRFSGFIDCGRLGVADRYQDIALATRDIAEELGGEWADRFLVLYGIAAPDSQRIAFYRLLDEFF*"/></Q></Feature><Feature recentID="18" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="6598" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="5807-6598" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="6599-6667" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MSIQHFRVALIPFFAAFCLPVFA,HPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRIDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPVAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW*"/></Q></Feature><Feature recentID="19" name="Kozak sequence" type="regulatory" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="700-709" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;vertebrate consensus sequence for strong initiation of translation (&lt;a href=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot; title=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot;&gt;Kozak, 1987&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="regulatory_class"><V predef="other"/></Q></Feature><Feature recentID="20" name="Trex1-m" directionality="1" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="1743" maxFusedRunOn="1743"><Segment range="706-1647" color="#ffcc00" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MGSQTLPHGHMQTLIFLDLEATGLPSSRPEVTELCLLAVHRRALENTSISQGHPPPVPRPPRVVDKLSLCIAPGKACSPGASEITGLSKAELEVQGRQRFDDNLAILLRAFLQRQPQPCCLVAHNGDRYDFPLLQTELARLSTPSPLDGTFCVDSIAALKALEQASSPSGNGSRKSYSLGSIYTRLYWQAPTDSHTAEGDVLTLLSICQWKPQALLQWVDEHARPFSTVKPMYGTPATTGTTNLRPHAATATTPLATANGSPSNGRSRRPKSPPPEKVPEAPSQEGLLAPLSLLTLLTLAIATLYGLFLASPGQ"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  ¥<Notes>
<UUID>05de09ab-8c80-436d-bd77-ba9f7f14fbea</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<CustomMapLabel>pCMV-Trex1(mouse)-3Ã—HA-Neo</CustomMapLabel>
<UseCustomMapLabel>1</UseCustomMapLabel>
<Created UTC="5:0:4">2019.1.23</Created>
<LastModified UTC="1:23:30">2025.9.21</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  Y     K         
?????                                                                                                       ÿ d      DO  d               E              ÿÿÿÿYô? P                                                                                                                                                             k<StrandColors><TopStrand><ColorRange range="704..718" colors="green"/><ColorRange range="862..862" colors="magenta"/><ColorRange range="1509..1509" colors="magenta"/></TopStrand><BottomStrand><ColorRange range="704..718" colors="green"/><ColorRange range="862..862" colors="magenta"/><ColorRange range="1509..1509" colors="magenta"/></BottomStrand></StrandColors>   3<?xml version="1.0"?><EnzymeVisibilities vals=""/>
   )<?xml version="1.0"?><CustomEnzymeSets/>
